Interferon Alpha Association with Neuromyelitis Optica
نویسندگان
چکیده
منابع مشابه
Interferon Alpha Association with Neuromyelitis Optica
Interferon-alpha (IFN- α ) has immunoregulatory functions in autoimmune inflammatory diseases. The goal of this study was to determine occurrence and clinical consequences of IFN- α in neuromyelitis optica (NMO) patients. Thirty-six NMO and 41 multiple sclerosis (MS) patients from a population-based retrospective case series were included. Expanded Disability Status Scale (EDSS) score and MRI f...
متن کاملTreatment of neuromyelitis optica/neuromyelitis optica spectrum disorders with methotrexate
BACKGROUND To review our experience using methotrexate as a single long-term immunosuppressant (IS) therapy in neuromyelitis optica/neuromyelitis optica spectrum disorders (NMO/NMOSD). METHODS We performed a retrospective chart review of all patients with a diagnosis of NMO/NMOSD, supported by a positive NMO-IgG testing, who were treated with methotrexate. A paired sample 2 tailed t test was ...
متن کاملNeuromyelitis Optica
An 11-year-old girl developed sudden visual loss in her left eye, preceding subacute myelitis by 9 months. Multifocal lesions in the central nervous system were demonstrated by magnetic resonance imaging. Although unilateral blindness is unusual, the clinical findings predominantly involving the optic nerve and spinal cord were consistent with the diagnosis of neuromyelitis optica (NMO). This c...
متن کاملAssociation of neuromyelitis optica with severe and intractable pain.
OBJECTIVE To contrast differences in pain and treatment outcomes between neuromyelitis optica (NMO) and multiple sclerosis (MS). DESIGN Retrospective, cross-sectional cohort study. SETTING Academic MS center. PATIENTS Complete ascertainment of an academic MS center cohort of NMO and an MS comparison sample cohort. MAIN OUTCOME MEASURES Current pain was quantified by a 10-point scale and...
متن کاملInterferon-β1b Increases Th2 Response in Neuromyelitis Optica
A Japanese randomized controlled study showed that Interferon â (IFN-â1b) therapy is clinically effective in decreasing the frequency of attacks in multiple sclerosis (MS), even in optico-spinal MS (OSMS). However, recent studies have shown that IFN-â (IFN-â1a/IFN-â1b) treatment was not effective in neuromyelitis optica (NMO) patients and that the diminished benefit of IFN-â treatment in NMO m...
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ژورنال
عنوان ژورنال: Clinical and Developmental Immunology
سال: 2013
ISSN: 1740-2522,1740-2530
DOI: 10.1155/2013/713519